Vaccinal prevention of Tick-Borne Encephalitis in chelyabinsk Region: Dynamics of Vaccination, population Immunity, Analysis of TBE cases in Vaccinated persons

The Chelyabinsk Region (Southern Urals) is high endemic territory. The TBE incidence is 3.57 ± 1.7 per 100 000 of population. A level of vaccination against TBE increased from 0.3 to 34.8% in 1999 - 2013. Specific immunity of population in 35.9% is connected with vaccination, in 64.1% with natural immunity consequently latent contact with TBE virus. Dynamics of vaccinal prevention, increasing of population immunity in different landscapes, and in different age groups were studied. 77.7% of TBE patients did not vaccinated, 18.2% received of specific immunoglobulin at postexposition and 3.7% persons were vaccinated. Unusual lethal case in patient, who received 8 doses of vaccine is analysed in this article.

клещевой энцефалит, вакцинопрофилактика, популяционный иммунитет, вакцинальный иммунитет, сибирский подтип вируса, Челябинская область, TBE, vaccination, Chelyabinsk region, Southern Urals, population immunity

1. Onishchenko G.G., Fedorov Yu.M., Pakskina N.D. Organization of supervision for Tick-borne encephalitis and its preventive maintenance in Russian Federation. Voprosy virusologii. 2007; 5: 8 – 10 (in Russian).

2. Vorobieva, M.S., Merculov V.A., Ladyzhenskaya I.P., Rukavishnikov A.V., Shevtsov V.A. History of creation and quality evaluation of modern Tick-borne encephalitis vaccines of domestic and foreign production. Scientific center of medical products bulletin. 2013; 3: 40 – 44 (in Russian).

3. Kolyasnikova N.M. Monitoring of TBE virus populations in Ural, West Siberian and Nord-Western regions of Russia (Virologic and molecular-biologic investigetion). Doctorat of med. sci. Moscow; 2008 (in Russian).

4. Gerasimov S.G., Druzhinina T.A., Karan L.S., Kolyasnikova N.M., Baranova N.S., Levina L.S. The features of Tick-borne encephalitis in Yaroslavl region in modern phase. The problem of evolution of the infection. Epidemiologia i infektsionnye bolezni. 2014; (19) 4: 37 – 44 (in Russian).

5. Romanenko V.V., Ankudinova A.V., Kilyachina A.S. Efficiency of the TBE vaccination program in Sverdlovsk region. J. of Ural med. Academy. 2010; 21: 125 – 132 (in Russian).

6. Tick-borne Encephalitis prevention Sanitary and epidemiologic rules and regulations SP 3.1.3.2352-07. Moscow. 2008.

7. Efimova A.R., Karan L.S., Drozdova O.M., Grigor’eva Ya E., Frolova N.A., Sheiderova I.D. et al. Modern epidemiological situation of Tick-borne Encephalitis and genetic variability TBEV in Kemerovo region territory. Meditsinskaya virusologia. 2015; XXIV: Dx.doi.org/10.15610/29_1_1. (in Russian).

8. Balakhonov S.V., Pakskina N.D., Nikitin A. Ya., Noskov A.K., Andaev E.I., Chesnokova M.V. et al. Epidemiological situation on Tick-borne encephalitis in the territory of Russian Federation in 2012 and prognosis for 2013. Problems of peculiar dangerous infections, 2013; 1: 34 – 37 (in Russian).

9. Noskov A.K., Il’in V.P., Andaev E.I., Pakskina N.D., Verigina E.V., Balakhonov S.V. Morbidity rates as regards Tick-borne encephalitis in Russian Federation and across Federal Districts in 2009-2013. Epidemiological Situation in 204 and prognosis for 2015. Problemy osobo opasnyh infektsiy. 2015; 1: 46 – 50 (in Russian).

10. Pogodina V.V., Karan L.S., Kolyasnikova N.M., Levina L.S., Malenko G.V., Gamova E.G. et. al. Tick-borne Encephalitis evolution and the problem of TBE virus evolution. Voprosy virusologii. 2007; 5: 16 – 20 (in Russian).

11. ZlobinV.I., Malov I.V., Lvov D.K. Epidemiology and prevention of Tick-borne Encephalitis in Russian Federation. In book Eds.: V.V. Vlasov, V.E. Repin, Tick- borne encephalitis in Siberian region, Novosibirsk. Publishing House of Siberian branch of the Russian Academy of sciences, 2011; 73 – 83 (in Russian).

12. Medunitsyn N.Y., Mironov A.N. Vaccines. New approaches for the enhancement of vaccination efficiency and safety.Voprosy virusologii. 2012; 1: 43 – 51 (in Russian).

13. Heinz F., Holtzman H., Essl A., Kundt M. Analysis of officiency of Tick-borne encephalitis vaccination in the population in the natural foci of Austria. Voprosy virusologii. 2008. 2: 19 – 27 (in Russian).

14. Volkova L.I. Tick-borne encephalitis in Middle Urals: clinical and epidemiological analysis of acute and chronic forms, improvement of special medical service in endemic territory. PhD of med. sci. diss. Ekaterinburg; 2009 (in Russian).

15. Kunz Ch. TBE vaccination and the Austrian experiensе. Vaccine. The official journal of international society for vaccines. 2003; 21 (1): 50 – 55.

16. Pogodina V.V., Levina N.S., Skrynnik S.M., Travina N.S., Karan L.S., Kolyasnikova N.M. et al. Tick-borne Encephalitis with fulminant course and lethal outcome in patient with plural vaccination. Voprosy virusologii. 2013; 2: 33 – 37 (in Russian).

17. Luchinina S.V., Stepanova O.N., Pogodina V.V., Sten’ko E.A., Chirkova G.G., Gerasimov S.G. et al. Modern epidemiologic situation of Tick-borne encephalitis in Chelyabinsk Region of Russia. Epidemiologia & Vaccinal Prevention. 2014; 3: 32 – 37 (in Russian).

18. Karan L.S., Braslavskaya S.I., Myazin A.E. The development of methods for tick-borne encephalitis virus detection and genotyping based on amplification technologies. Voprosy virusologii. 2007; 6: 17 – 21 (in Russian).

19. Konkova-Reidman A.B., Zlobin V.I. Specific and nonspecific prevention of Tick-borne Encephalitis and Ixodes borrelioses in the Southern Urals. Siberian Medical journal, 2012; 4: 71 – 74 (in Russian).

20. Mironov I.L. Tick-borne encephalitis in Miass city (Chelabinsk district). News of higher educational establishment. Ural region (Izvestia vysshih uchebnykh zavedeniy. Ural’skiy region). 2010; 2: 72 – 75 (in Russian).

21. Yastrebov V.K., Hazova T.G. Optimization of epidemiological control system and prevention of Tick-borne encephalitis. Epidemiologia i vaktsinoprofilaktika. 2012; 1: 19 – 24 (in Russian).

22. Morozova O.V., Grishechkin A.E., Konkova-Reidman A.B. Quantitative assay of DNA of borrelia and bartonella and RNA of Tick-borne encephalitis virus in the ticks Ixodes persulcatus collected in Chelyabinsk region. Molecularnaya genetica, microbiologia i virusologia, 2011; 1: 35 – 38 (in Russian).

23. Pogodina V.V., Luchinina S.V., Stepanova O.N., Sten’ko E.A., Gorfinkel A.N., Karmysheva V.Ya. Unusual case of lethal Tick-borne encephalitis in patient vaccinated with vaccines produced from different viruses strains (Chelyabinsk region). Epidemiologia i infektsionnye bolezni. 2015; 20 (1): 56 – 65 (in Russian).